Blood pressure swings and recovery after ischemic stroke
Official title: Blood Pressure Variability and Ischemic Stroke Outcome (BP-VISO)
Funded at Yale University · NIH-11251806 · Data updated 2026-11-12
This project tests whether reducing dangerous blood pressure swings after an acute ischemic stroke helps people recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $472,206 |
| NIH project number | 5R01NS130189-04 |
| Project ID | NIH-11251806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people hospitalized with an acute anterior-circulation ischemic stroke who can be evaluated soon after arrival (within about 12 hours).
✕Less likely to help
People with hemorrhagic stroke, posterior-circulation strokes, or those who arrive too late after symptom onset are unlikely to be eligible or to directly benefit from this study.
What this research studies
If you join, researchers will enroll 150 people who had an anterior circulation ischemic stroke and monitor blood pressure closely to measure short- and long-term variability. They will use portable MRI within about 12 hours of arrival and again at 72 hours to see how stroke size, growth, and bleeding relate to blood pressure swings. At the bedside they will use a pupillometer to measure autonomic nervous system function and compare how different blood pressure medicines affect variability. The goal is to link blood pressure patterns and biology to real recovery outcomes.
Why it matters
Potential benefit: If successful, this work could lead to ways to reduce harmful blood pressure swings after stroke and improve recovery and survival.
How similar studies have gone: Previous retrospective studies have linked higher blood pressure variability to worse outcomes after stroke, but prospective studies testing whether lowering variability improves recovery are lacking.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: De Havenon, Adam H. — Yale University
- Study coordinator: De Havenon, Adam H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.