Blood pressure and nerve responses during exercise in people with chronic kidney disease
Neurovascular Regulation During Exercise in Humans With Chronic Kidney Disease
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-11121946
This project looks at why adults with chronic kidney disease have larger blood pressure and nerve reactions during exercise and whether acidic changes in muscles cause this.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11121946 on ClinicalTrials.gov |
What this research studies
If you join, you would complete supervised bouts of aerobic exercise while researchers measure your blood pressure and the nerve signals that control it. They will compare responses in people with CKD to those without and look for signs that muscle acidity (lower pH) activates those nerve signals. The team will use measures of sympathetic nerve activity and muscle interstitial indicators to link acidity with blood pressure spikes. Results are intended to reveal mechanisms that explain exercise-related blood pressure surges in CKD.
Who could benefit from this research
Good fit: Ideal participants are adults (21+) with chronic kidney disease who are medically cleared and able to perform supervised aerobic exercise.
Not a fit: People who cannot safely exercise, those with unstable or end-stage conditions that prevent participation, or individuals without CKD-related exercise blood pressure problems may not receive direct benefit.
Why it matters
Potential benefit: If successful, this work could point to new ways to reduce exercise-related blood pressure spikes, lower cardiovascular risk, and improve exercise tolerance for people with CKD.
How similar studies have performed: Previous studies have shown exaggerated sympathetic and blood pressure responses to exercise in CKD and provide preliminary evidence that muscle acidosis may trigger these responses, but directly targeting this mechanism is a relatively new approach.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARK, JEANIE — EMORY UNIVERSITY
- Study coordinator: PARK, JEANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.