Blood metabolites that could predict stomach cancer risk
Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
['FUNDING_R37'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-11400206
Researchers will look for patterns in blood chemicals that help spot people at higher risk of stomach (gastric) cancer using samples from large groups of adults.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11400206 on ClinicalTrials.gov |
What this research studies
This project measures many small molecules (metabolites) in blood samples collected from large, ongoing cohorts and compares people who later developed gastric cancer with similar people who did not. The team will use advanced metabolomics lab tests and statistical analyses to find metabolite patterns linked to future stomach cancer. Promising markers will be checked across multiple centers and populations, including people with Helicobacter pylori infection and those of Asian background. The aim is to develop non-invasive blood-based risk tools to guide screening and prevention.
Who could benefit from this research
Good fit: Ideal candidates are adults enrolled in participating cohorts or clinics—especially those with H. pylori infection, a family history of gastric cancer, or of Asian descent—who can provide blood samples and health information.
Not a fit: People who already have advanced or diagnosed stomach cancer are unlikely to receive direct benefit from a prevention-focused risk-marker project.
Why it matters
Potential benefit: If successful, this work could lead to a simple blood test to identify people at higher risk of stomach cancer so they can get earlier screening or prevention.
How similar studies have performed: Metabolomics has found risk markers for other cancers and small prior studies suggested possible metabolite signals for gastric cancer, but large multi-center prospective validation remains novel.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHU, XIANG — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SHU, XIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.