Blood metabolite markers linked to stomach cancer risk
Circulating metabolites as novel risk biomarkers for gastric cancer: a large multi-center prospective investigation
They are looking for patterns in blood metabolites that could help spot people who are more likely to develop stomach (gastric) cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11193803 on NIH RePORTER |
What this research studies
Researchers will use stored blood plasma from large, multi-center cohorts and compare people who later developed gastric cancer to similar people who did not. Advanced metabolomics will measure many small molecules in the blood to find patterns tied to higher cancer risk. Promising metabolite signals will be validated across different centers and populations to improve reliability. The aim is to create a non-invasive blood-based risk signal that could help guide screening and prevention.
Who could benefit from this research
Good fit: Ideal candidates are adults enrolled in the participating cohorts, particularly people with H. pylori infection, a family history of gastric cancer, or from higher-risk populations such as some Asian groups.
Not a fit: People already diagnosed with stomach cancer are unlikely to receive direct benefit because the work focuses on predicting future risk rather than treating existing disease.
Why it matters
Potential benefit: If successful, this could lead to a simple blood test that identifies people at higher risk of stomach cancer so they can receive earlier screening or preventive care.
How similar studies have performed: Metabolomics has revealed risk signals for other cancers in past prospective studies, but large prospective metabolomics work focused specifically on gastric cancer is relatively new and less established.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Shu, Xiang — Sloan-Kettering Inst Can Research
- Study coordinator: Shu, Xiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.