Blood clotting and inflammation in placental abruption
Coagulation-inflammation crosstalk in placental abruption
The team is looking at how blood clotting and immune reactions cause placental abruption in pregnant people to find ways to prevent harm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11141032 on NIH RePORTER |
What this research studies
This project uses mouse models that lack a protective clotting receptor to reproduce early events that lead to placental abruption. Researchers track how clots, immune cells, and inflammatory enzymes like myeloperoxidase and modified histones drive tissue damage at the placenta. They test how blocking a key clotting receptor (Par4) changes those reactions and the chance of abruption. Findings from mice are compared with human placental samples to connect the lab results to human pregnancy.
Who could benefit from this research
Good fit: People who are pregnant or planning pregnancy with a prior placental abruption or other high-risk features, and those willing to donate placental tissue after delivery, would be most relevant to this research.
Not a fit: People who are not pregnant or who have no placental or clotting-related concerns would be unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, the work could point to new ways to prevent or treat placental abruption by targeting clotting or inflammation pathways.
How similar studies have performed: Previous animal and tissue studies have linked clotting and inflammation to pregnancy complications, but translating these specific molecular targets into therapies is still largely unproven.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Sood, Rashmi — Medical College of Wisconsin
- Study coordinator: Sood, Rashmi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.