Blood clot risk when young people start estrogen
Thrombosis Risk in Adolescents and Young Adults Starting Estrogen
This project will measure how starting estrogen changes blood clotting and how doctors decide whether to prevent clots in teens and young adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11124166 on NIH RePORTER |
What this research studies
If you are a teen or young adult starting estrogen, you may be asked to join and give blood samples over time so researchers can track changes in clotting factors. The team will compare these lab changes with medical and family histories to see who develops higher clotting risk. Doctors who treat youth will be surveyed and interviewed about when they recommend blood thinners or other precautions. Together, the lab and clinician data will be used to make clearer guidance for preventing blood clots in young people on estrogen.
Who could benefit from this research
Good fit: Ideal candidates are adolescents and young adults who are starting or have recently started estrogen therapy and can provide blood samples and medical/family history.
Not a fit: People who are not taking estrogen or those with active clotting conditions already on long-term anticoagulation may not receive direct benefit from this study.
Why it matters
Potential benefit: If successful, this work could help identify which young people starting estrogen are at higher risk for blood clots so clinicians can offer targeted prevention.
How similar studies have performed: Prior studies have linked estrogen to clot risk in adults, but measuring coagulation changes specifically in youth starting estrogen is limited, so this approach is relatively new.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Mullins, Tanya L. Kowalczyk — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Mullins, Tanya L. Kowalczyk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.