Blood chemical markers of smoking exposure across different ethnic groups
Untargeted Adductomics to Characterize Ethnic Differences in the Exposome of Smokers
['FUNDING_P01'] · UNIVERSITY OF MINNESOTA · NIH-11180290
This project looks at chemicals attached to blood proteins to find differences in smoking exposure among people from different ethnic backgrounds.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11180290 on ClinicalTrials.gov |
What this research studies
Researchers collect blood samples from smokers and use an untargeted 'adductomics' approach to find chemicals stuck to hemoglobin that reflect lifetime exposures. They compare these exposure patterns across ethnic groups while accounting for lifestyle factors like diet and alcohol. Advanced laboratory chemical scanning and bioinformatics are used to spot and identify unexpected exposure markers. The team aims to connect exposure differences to the higher lung cancer rates seen in some groups.
Who could benefit from this research
Good fit: Ideal participants are current or former cigarette smokers—especially African American and Native Hawaiian individuals—willing to provide blood samples and information about smoking and lifestyle.
Not a fit: People who have never smoked or whose health problems are unrelated to tobacco exposure are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help explain why some ethnic groups have higher smoking-related lung cancer and guide better prevention, screening, or tailored counseling.
How similar studies have performed: Targeted biomarker studies have linked some blood adducts to smoking and cancer risk, but untargeted adductomics is a newer approach that is less proven for explaining ethnic disparities.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TRETYAKOVA, NATALIA Y — UNIVERSITY OF MINNESOTA
- Study coordinator: TRETYAKOVA, NATALIA Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.