Blood chemical exposures and B‑cell blood cancer risk
Mapping the blood cancer exposome for environmental risk profiles of mature B-cell neoplasms
Researchers will use advanced blood chemical testing and AI to find environmental exposures linked to B‑cell blood cancers like non‑Hodgkin lymphoma and multiple myeloma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11233248 on NIH RePORTER |
What this research studies
If you take part, researchers will analyze stored or new blood samples taken before diagnosis using high‑resolution mass spectrometry to measure thousands of chemicals in your blood. They will compare people who later developed mature B‑cell cancers to matched controls in a nested case–control design to identify exposure patterns that occur before disease. Advanced algorithms and big‑data methods will be used to pick out chemical signatures and mixtures tied to specific B‑cell cancer subtypes. The team aims to discover previously unknown environmental risk factors that could help guide prevention or earlier detection.
Who could benefit from this research
Good fit: Ideal participants are adults with available pre‑diagnosis blood samples or those willing to provide blood and exposure history, especially people at higher risk for B‑cell cancers.
Not a fit: People seeking immediate treatment benefits or those without available blood samples or exposure information are unlikely to get direct clinical benefit from this research.
Why it matters
Potential benefit: If successful, this could reveal environmental chemicals or exposure patterns that help prevent B‑cell cancers or allow earlier detection for people at risk.
How similar studies have performed: High‑resolution exposome profiling is a new approach with promising technical progress but has not yet been widely applied to mature B‑cell cancers, so findings would be largely novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Walker, Douglas Ian — Emory University
- Study coordinator: Walker, Douglas Ian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.