Blood and urine multi-omics to better classify chronic kidney disease
Multi-Omics for Chronic Kidney Disease
This project uses detailed blood and urine tests to find molecular subtypes of chronic kidney disease for adults with non-diabetic CKD.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11123472 on NIH RePORTER |
What this research studies
You would be followed over time while researchers collect blood and urine samples to measure genetics, epigenetics, RNA, proteins, and metabolites. About 200 people with CKD and 100 people without CKD will be enrolled and sampled repeatedly to look for molecular patterns that separate disease subtypes. The team will use these multi-omic data to find non-invasive molecular signatures that could classify non-diabetic CKD beyond current tests. This work is done at Columbia as part of a larger multi-omics consortium aiming to speed development of precision medicine tools for kidney disease.
Who could benefit from this research
Good fit: Adults with chronic kidney disease—especially those with non-diabetic CKD—who can give blood and urine samples and attend follow-up visits.
Not a fit: People with only diabetic kidney disease, acute kidney injury, or who cannot come for follow-up visits may not directly benefit from this work.
Why it matters
Potential benefit: If successful, this could lead to blood or urine tests that help doctors diagnose specific molecular types of CKD and guide more personalized care.
How similar studies have performed: Multi-omics has produced useful biomarkers in other diseases and early CKD studies are promising, but large-scale molecular subclassification of non-diabetic CKD is still new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Kiryluk, Krzysztof — Columbia University Health Sciences
- Study coordinator: Kiryluk, Krzysztof
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.