Blood and urine multi-omics tests to predict late lung and kidney damage after radiation
Advanced development of multi-omics based assays to predict late radiation organinjuries - the DEARE-Watch project
['FUNDING_U01'] · GEORGETOWN UNIVERSITY · NIH-11332007
This project develops blood and urine tests to tell adults who survived significant radiation exposure whether they are likely to develop later lung or kidney problems.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11332007 on ClinicalTrials.gov |
What this research studies
From a patient perspective, researchers will look for patterns of many different molecules in blood and urine collected soon after radiation exposure to find early warning signs of future organ damage. They will build algorithmic panels called LungWatch and KidneyWatch that combine these molecular signals to predict who will develop late lung or kidney injury. Work uses prior animal and human sample data and will validate the tests with additional samples and analytic development to make the tests reliable. The goal is minimally invasive monitoring so doctors can watch high-risk people more closely and start treatments earlier.
Who could benefit from this research
Good fit: Ideal candidates are adults who experienced significant acute radiation exposure and can provide early blood or urine samples or are available for follow-up monitoring.
Not a fit: People without a history of substantial radiation exposure or whose exposure occurred long ago outside the early biomarker window are unlikely to benefit.
Why it matters
Potential benefit: If successful, these tests could enable earlier monitoring and targeted treatment that reduces long-term lung and kidney damage after radiation exposure.
How similar studies have performed: Prior animal studies and retrospective analyses of human samples have shown promising multi-omics signals for predicting late organ injury, and this project aims to further develop and validate those panels for clinical use.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEEMA, AMRITA KAUR — GEORGETOWN UNIVERSITY
- Study coordinator: CHEEMA, AMRITA KAUR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Radiation Syndrome