Blood and gut immune cells talk to shape tolerance and inflammation
Official title: Cell-cell interactions driving gut inflammation and tolerance
Funded at Albert Einstein College of Medicine · NIH-11419653 · Data updated 2026-11-12
This grant explores how special gut immune cells decide between tolerating foods and fighting infections, with potential to improve treatment for food allergies and inflammatory bowel disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 5R00AI173537-04 |
| Project ID | NIH-11419653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with allergic to food or inflammatory gut conditions, or those at risk of these conditions, who could benefit from future therapies.
✕Less likely to help
The study itself is basic research; direct benefits to participants are not guaranteed, and it does not involve immediate patient treatment.
What this research studies
Researchers will use advanced labeling techniques to map how dendritic cells in the gut interact with CD4+ T cells, shaping whether responses become tolerant or inflammatory. By combining genetic tools, imaging, and transcriptomics, the study aims to uncover the cellular decisions that drive gut balance. The work is designed to translate into strategies that could reduce food allergies and inflammatory gut conditions in people. This project is conducted in a way that could eventually lead to new therapies targeting the gut immune network.
Why it matters
Potential benefit: If successful, the findings could inform new approaches to prevent or treat food allergies and inflammatory bowel disease.
How similar studies have gone: Prior work using similar immune-labeling approaches has yielded insights into gut immune interactions, suggesting this strategy could reveal actionable mechanisms.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Campos Canesso, Maria Cecilia — Albert Einstein College of Medicine
- Study coordinator: Campos Canesso, Maria Cecilia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.