Blocking the movement of cells to prevent invasive prostate cancer
Official title: Preventing invasive prostate cancer
Funded at University of Nebraska Medical Center · NIH-10931324 · Data updated 2026-11-12
This study is testing a new treatment called KBU2046 that aims to stop prostate cancer from spreading by blocking the movement of cancer cells, and it's designed for anyone concerned about preventing invasive prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $508,994 |
| NIH project number | 5R01CA276846-02 |
| Project ID | NIH-10931324 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are men at high risk for developing prostate cancer, particularly those with early-stage disease.
✕Less likely to help
Patients with advanced prostate cancer or those who have already been diagnosed with invasive cancer may not benefit from this research.
What this research studies
This research focuses on preventing invasive prostate cancer by inhibiting the movement of cancer cells. The team has developed a new agent called KBU2046, which selectively targets and inhibits cell motility, a key factor in the progression of cancer. Through a series of advanced studies, including biochemical and bioinformatics approaches, the researchers aim to identify how KBU2046 works at the molecular level and its potential to prevent the development of invasive cancer. This innovative approach could lead to new strategies for cancer interception and prevention.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of invasive prostate cancer, improving outcomes for patients.
How similar studies have gone: While the approach of selectively inhibiting cell motility is novel, similar strategies targeting cancer prevention have shown promise in other studies.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Bergan, Raymond C. — University of Nebraska Medical Center
- Study coordinator: Bergan, Raymond C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.