Blocking sEH to protect brain blood vessels in Alzheimer's
Vascular mechanisms of inhibition of sEH as a novel therapy for AD/ADRD
['FUNDING_R01'] · UNIVERSITY OF MISSISSIPPI MED CTR · NIH-11297551
This project is trying to find out whether blocking an enzyme called sEH can improve brain blood flow and memory in people with Alzheimer's disease and related dementias.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSISSIPPI MED CTR (nih funded) |
| Locations | 1 site (JACKSON, UNITED STATES) |
| Trial ID | NIH-11297551 on ClinicalTrials.gov |
What this research studies
If I took part in this research, the team would study how an enzyme called soluble epoxide hydrolase (sEH) affects brain blood vessels, inflammation, and thinking. They combine laboratory drug tests using an sEH blocker (TPPU) in animal models with analysis of human genetic data and blood molecules linked to vascular health. The researchers measure brain blood flow, vessel responses, inflammatory oxylipin levels, and cognitive changes to look for matching patterns between animals and people. The goal is to determine whether targeting sEH could become a new treatment option for people with Alzheimer's or diabetes-related dementia.
Who could benefit from this research
Good fit: People with Alzheimer's disease or related dementias, especially those who also have diabetes or signs of reduced brain blood flow, would be the most likely candidates for related trials.
Not a fit: People whose cognitive problems are primarily from non-vascular causes or those with very advanced disease may be less likely to benefit.
Why it matters
Potential benefit: Could improve brain blood flow and help preserve thinking and memory for people with Alzheimer's and diabetes-related dementia.
How similar studies have performed: Preclinical studies in animal models showed that sEH inhibitors like TPPU improved cerebral blood flow and cognition, but human clinical testing remains limited.
Where this research is happening
JACKSON, UNITED STATES
- UNIVERSITY OF MISSISSIPPI MED CTR — JACKSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROMAN, RICHARD J. — UNIVERSITY OF MISSISSIPPI MED CTR
- Study coordinator: ROMAN, RICHARD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia, Alzheimer's disease and related disorders