Blocking Phlpp enzymes to protect cartilage in osteoarthritis
Phlpp phosphatases in osteoarthritis
['FUNDING_R01'] · MAYO CLINIC ROCHESTER · NIH-11168747
This work tests small drugs that block Phlpp enzymes to slow cartilage loss and reduce joint pain in adults with osteoarthritis.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11168747 on ClinicalTrials.gov |
What this research studies
Researchers are focusing on enzymes called Phlpp1 and Phlpp2 that are increased in human osteoarthritis cartilage. In mice, removing Phlpp1 or giving small drugs that block Phlpp1/2 protected cartilage and improved movement after joint injury. The team uses lab tests, mouse models, and experiments with human cartilage cells and tissues to see whether blocking Phlpp helps cartilage grow and reduces nerve signals linked to pain. The goal is to develop a drug approach that could slow joint damage and ease pain.
Who could benefit from this research
Good fit: Adults (age 21+) with osteoarthritis, especially those with knee pain and reduced mobility, would be the most relevant candidates for related clinical work.
Not a fit: People without osteoarthritis, those whose joint problems are driven mainly by non-cartilage issues (for example isolated ligament tears), or people who already had joint replacement surgery are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this work could lead to medicines that slow cartilage damage and reduce osteoarthritis pain, improving mobility and joint function.
How similar studies have performed: Preclinical mouse and cell studies showed protection from cartilage loss and reduced pain behaviors after removing or blocking Phlpp enzymes, but testing Phlpp-blocking drugs in people is still new.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WESTENDORF, JENNIFER J — MAYO CLINIC ROCHESTER
- Study coordinator: WESTENDORF, JENNIFER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.