Blocking harmful signals between glioblastoma and the brain's subventricular zone
Targeting Signaling Between Glioblastoma and the Subventricular Zone Niche
This work looks at blocking signals between glioblastoma tumors and the nearby subventricular zone to reduce tumor growth and spread in adults with GBM.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-11160553 on NIH RePORTER |
What this research studies
Researchers will use animal models that mimic glioblastomas near the lateral ventricles and will analyze image-guided human tumor biopsies to compare gene activity. The team studies how brain tumor initiating cells interact with neural progenitor cells and uses techniques like ATAC-seq to find the signaling pathways that drive growth and migration. Laboratory experiments will test whether disrupting those signals reduces tumor cell proliferation and movement. The aim is to find targets that could lead to new treatments for GBM that recurs or spreads because of influence from the subventricular zone.
Who could benefit from this research
Good fit: Adults with a diagnosis of glioblastoma, particularly tumors located close to the lateral ventricles or patients who can provide tumor biopsy samples, are the most relevant candidates.
Not a fit: Patients with brain tumors that are not glioblastoma, tumors far from the subventricular zone, or those unable to undergo biopsy or surgical sampling may not directly benefit from this research.
Why it matters
Potential benefit: If successful, this work could point to new therapies that slow tumor growth, lower recurrence, and improve outcomes for patients with GBM near the lateral ventricles.
How similar studies have performed: Previous studies have shown that tumors near the lateral ventricles behave more aggressively and that neural progenitor cells can boost tumor cell growth, but directly targeting the signaling between the SVZ and GBM is a relatively new approach with limited clinical success so far.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Guerrero-Cazares, Hugo — Mayo Clinic Jacksonville
- Study coordinator: Guerrero-Cazares, Hugo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.