Blocking cancer progression by targeting lymph node metastases
Official title: Targeting lymph node metastases to block cancer progression
Funded at Massachusetts General Hospital · NIH-11088828 · Data updated 2026-11-12
This study is looking at how we can use lymph nodes to help boost the immune system's fight against cancer, especially for people whose cancer has spread to these nodes, and aims to find ways to make immunotherapy work better for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $499,258 |
| NIH project number | 5R01CA284372-03 |
| Project ID | NIH-11088828 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with cancers that have spread to lymph nodes, particularly those experiencing immune suppression.
✕Less likely to help
Patients whose cancers have not metastasized to lymph nodes or those with non-cancerous conditions may not benefit from this research.
What this research studies
This research investigates how lymph nodes can be harnessed to create strong, lasting immune responses against cancer, particularly in patients with lymph node metastases. The study aims to understand the mechanisms by which cancer cells in these lymph nodes suppress the immune system, which contributes to cancer progression. By identifying these mechanisms, the research seeks to develop strategies to overcome immune suppression and enhance the effectiveness of immunotherapy for patients with metastatic cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy treatments that effectively target and eradicate metastatic cancers.
How similar studies have gone: Previous research has shown promising results in using immunotherapy to treat metastatic cancers, indicating that this approach may build on established successes.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Padera, Timothy P — Massachusetts General Hospital
- Study coordinator: Padera, Timothy P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.