Blocking a specific signaling pathway to prevent brain blood vessel abnormalities
Official title: Inhibiting Adrenomedullin signaling to prevent mammalian brain endothelial cell abnormalities and brain arteriovenous malformation
Funded at Ohio University Athens · NIH-11039958 · Data updated 2026-11-12
This study is looking at how blocking a specific signal in the brain might help keep blood vessels healthy and prevent problems like arteriovenous malformations (AVMs), which could lead to new, easier treatments for people dealing with this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio University Athens NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $75,500 |
| NIH project number | 5R03NS137135-02 |
| Project ID | NIH-11039958 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with brain arteriovenous malformations or those at risk of developing them.
✕Less likely to help
Patients with other types of vascular abnormalities not related to Adrenomedullin signaling may not benefit from this research.
What this research studies
This research investigates how inhibiting Adrenomedullin signaling can prevent abnormalities in brain endothelial cells, which are crucial for maintaining healthy blood vessels in the brain. By using both animal models and human cell cultures, the study aims to understand the role of this signaling pathway in the development of brain arteriovenous malformations (AVMs). If successful, this approach could lead to new pharmacological treatments that are less invasive than current surgical options for patients with AVMs.
Why it matters
Potential benefit: If successful, this research could provide a new, less invasive treatment option for patients suffering from brain arteriovenous malformations.
How similar studies have gone: While this approach is innovative, similar research has shown promise in targeting specific signaling pathways to treat vascular abnormalities.
Where this research is happening
-
Ohio University Athens
Athens, United States Active
Researchers
- Principal investigator: Nielsen, Corinne — Ohio University Athens
- Study coordinator: Nielsen, Corinne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.