Blocking a specific protein to treat sepsis
Complement C5 inhibition as sepsis therapy
['FUNDING_R01'] · OKLAHOMA MEDICAL RESEARCH FOUNDATION · NIH-11014353
This study is looking at whether blocking a protein called complement C5 can help people with sepsis, a serious infection that can harm organs, by testing it in models that mimic the condition caused by common bacteria.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OKLAHOMA MEDICAL RESEARCH FOUNDATION (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11014353 on ClinicalTrials.gov |
What this research studies
This research investigates how inhibiting a protein called complement C5 can help treat sepsis, a severe condition caused by infections that can lead to organ failure. The study will use models that mimic human sepsis caused by common bacteria, such as E. coli and Staphylococcus aureus, to explore how complement activation contributes to the disease. Researchers aim to determine if blocking C5 can prevent organ failure and improve survival rates in patients with sepsis. The approach includes testing different therapies that target both the complement and coagulation systems to provide better outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis, particularly those experiencing multiple organ failure due to bacterial infections.
Not a fit: Patients with sepsis caused by non-bacterial infections or those who do not meet specific clinical criteria may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve survival rates and outcomes for patients suffering from sepsis.
How similar studies have performed: Previous research has shown promise in targeting the complement system for sepsis treatment, indicating that this approach could be a meaningful advancement in therapy.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- OKLAHOMA MEDICAL RESEARCH FOUNDATION — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUPU, FLOREA — OKLAHOMA MEDICAL RESEARCH FOUNDATION
- Study coordinator: LUPU, FLOREA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.