Biomaterials to help the brain heal after ischemic stroke
Biomaterials Strategies to Promote Functional Recovery After Ischemic Stroke
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11227050
Researchers are trying a brain-injected scaffold together with natural particles from supportive brain cells to help adults regain function after ischemic stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11227050 on ClinicalTrials.gov |
What this research studies
This work uses a soft, injectable scaffold (MAP gel) placed into the stroke cavity to create a supportive environment for repair. It pairs that scaffold with extracellular vesicles from reactive astrocytes—tiny natural particles that carry growth and repair signals—and tests whether giving the vesicles intravenously alongside the implant improves recovery. Most experiments so far are in animal models where this combination improved tissue repair and function, and the team is refining methods to move toward human use. If translated to people, the approach could become a targeted way to boost the brain's own repair after an ischemic stroke.
Who could benefit from this research
Good fit: Adults who have experienced an ischemic stroke and are within a time window or clinical condition that would make them eligible for intracranial biomaterial therapy and related infusions.
Not a fit: People with hemorrhagic (bleeding) stroke, those with very long-standing or extremely large stroke cavities, or individuals unable to undergo brain procedures or IV treatments may not benefit.
Why it matters
Potential benefit: Could improve brain tissue repair and help people regain movement and other functions after ischemic stroke beyond what physical therapy alone provides.
How similar studies have performed: Related biomaterial and extracellular vesicle approaches have produced promising results in animal studies but have not yet been widely tested in people.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEGURA, TATIANA — DUKE UNIVERSITY
- Study coordinator: SEGURA, TATIANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.