Biology and genetics of metastatic disease in cancer
Official title: Biology and genetics of metastatic disease
Funded at Rockefeller University · NIH-11404085 · Data updated 2026-11-12
This grant explores how cancer spreads by studying the genes and molecules that drive metastasis, with a focus on ApoE and related pathways that may be targets for new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 7, 2022 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,017,000 |
| NIH project number | 5R35CA274446-05 |
| Project ID | NIH-11404085 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with cancer at risk of or facing metastatic disease, especially those with breast cancer or other solid tumors where ApoE signaling may play a role.
✕Less likely to help
If metastasis is not driven by ApoE-related pathways in a patient’s cancer, benefits may be limited.
What this research studies
Researchers study the molecular changes that enable cancer to spread, including how microRNAs and ApoE variants influence metastasis. The work looks at how these changes affect blood vessels, immune interactions, and tumor invasiveness. Findings have already spurred early clinical trials exploring metastasis-targeting therapies for patients with advanced cancers. The project aims to translate basic biology into strategies that could prevent or slow metastatic progression in people with cancer.
Why it matters
Potential benefit: Possible new therapies that slow or stop cancer spread could extend survival and improve quality of life for patients with metastatic cancer.
How similar studies have gone: Preclinical work and early human trials have shown proof-of-concept for metastasis-targeting approaches based on ApoE signaling.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Tavazoie, Sohail F. — Rockefeller University
- Study coordinator: Tavazoie, Sohail F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.