BioCyc, MetaCyc, and EcoCyc knowledge bases expansion with AI assistance
Official title: The BioCyc, MetaCyc, and EcoCyc Knowledge Bases
Funded at Sri International · NIH-11421654 · Data updated 2026-11-12
Aims to speed up and improve the BioCyc family of knowledge bases that map genomes and metabolic pathways, using AI to accelerate data curation for researchers who study microbes and metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sri International NIH-funded |
| Lab location | 1 site (Menlo Park, United States) |
| Project start | September 30, 2023 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,667,812 |
| NIH project number | 2R24GM150703-03A1 |
| Project ID | NIH-11421654 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patients directly (this is a bioinformatics resource development grant).
✕Less likely to help
Patients are not direct participants in this grant.
What this research studies
This project plans to expand BioCyc’s collection of knowledge bases, including EcoCyc and MetaCyc, by enhancing data curation and integration of new findings. An AI-assisted workflow will help curators find and incorporate recent scientific results, improving the accuracy and breadth of pathway and enzyme information. Researchers and educators who rely on EcoCyc and MetaCyc will have access to a richer, up-to-date resource for understanding bacterial metabolism and related pathways.
Why it matters
Potential benefit: If successful, clinicians and scientists could access more accurate and comprehensive metabolic maps to support research, biodesign, and educational efforts.
How similar studies have gone: BioCyc databases have a history of wide usage and impact in research, with ongoing improvements supporting broader discovery.
Where this research is happening
-
Sri International
Menlo Park, United States Active
Researchers
- Principal investigator: Karp, Peter D — Sri International
- Study coordinator: Karp, Peter D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.