Bile acids affect immune cells in tumors
Bile acids restrict functional reprogramming of myeloid-derived suppressor cells in tumor beds
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-10909092
This study is looking at how bile acids affect certain immune cells that can make it harder for your body to fight cancer, with the goal of finding new ways to boost cancer treatments and help patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10909092 on ClinicalTrials.gov |
What this research studies
This research investigates how bile acids influence myeloid-derived suppressor cells (MDSC) in the tumor environment, which are known to hinder the body's immune response against cancer. The study aims to understand the signaling pathways activated by these cells under stress conditions in tumors and how modifying these pathways can potentially enhance anti-tumor immunity. By exploring the role of bile acids in this process, the research seeks to identify new therapeutic strategies that could improve cancer immunotherapy outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with various types of cancers who are undergoing immunotherapy.
Not a fit: Patients who do not have cancer or those whose cancer is not responsive to immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune system's ability to fight cancer.
How similar studies have performed: Other research has shown promising results in manipulating immune cell functions to improve cancer treatment outcomes, suggesting that this approach may also be effective.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUEZ, PAULO CESAR — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: RODRIGUEZ, PAULO CESAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers