Better ways to measure key proteins for Type 1 Diabetes
Official title: Robust Mass Spectrometric Protein/Peptide Assays for Type 1 Diabetes Clinical Applications
Funded at Battelle Pacific Northwest Laboratories · NIH-11120936 · Data updated 2026-11-12
This project aims to create more accurate tests for proteins and hormones in people with Type 1 Diabetes, especially children and young adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | July 21, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $930,427 |
| NIH project number | 5U01DK137113-03 |
| Project ID | NIH-11120936 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant to patients, particularly children and young adults, living with or at risk for Type 1 Diabetes.
✕Less likely to help
Patients without Type 1 Diabetes or those not interested in advanced disease monitoring methods would not directly benefit from this specific assay development.
What this research studies
Type 1 diabetes often affects children and young adults, and it can be hard to track how the disease is changing or if treatments are working. Current tests for important proteins and hormones, like insulin, might not always be precise enough. This project is developing new, highly reliable tests using a method called mass spectrometry. These new tests will help doctors better understand disease progression and how well new treatments are working for patients.
Why it matters
Potential benefit: If successful, these new tests could provide doctors with more accurate tools to monitor Type 1 Diabetes and tailor treatments more effectively.
How similar studies have gone: While mass spectrometry is a known technique, developing highly specific, multiplexed assays for these particular Type 1 Diabetes markers using this approach is a novel and promising area.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Qian, Wei-Jun — Battelle Pacific Northwest Laboratories
- Study coordinator: Qian, Wei-Jun
Related research
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A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.