Better ways to measure heart and stroke outcomes over time
Novel Statistical Methods for Complex Time-to-Event Data in Cardiovascular Clinical Trials
Researchers are developing new statistical tools to combine and prioritize different heart and stroke events for people enrolled in cardiovascular trials.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11171709 on NIH RePORTER |
What this research studies
This project will build and test new methods that count more than just a patient’s first heart-related event and that give greater priority to more serious outcomes like death. The team will adapt techniques to correct for patients lost to follow-up and use information from before and after treatment to make estimates more reliable. They will also create calculators to help plan future trials (how many people are needed) and to measure how well treatments work overall and within subgroups. These tools will be developed using data from cardiovascular trials and validated with simulations and statistical proofs.
Who could benefit from this research
Good fit: Ideal candidates would be people taking part in cardiovascular clinical trials that track multiple events such as heart failure, heart attack, hospitalization, or stroke.
Not a fit: People without cardiovascular conditions or those not enrolled in trials that track multiple event types are unlikely to see direct benefits from this work in the short term.
Why it matters
Potential benefit: If successful, these tools could make clinical trials more accurate and efficient, helping effective heart and stroke treatments reach patients faster.
How similar studies have performed: Some recent approaches that count multiple events have shown promise, but the specific weighted and censoring-corrected methods proposed here are relatively new and still need validation.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Mao, Lu — University of Wisconsin-Madison
- Study coordinator: Mao, Lu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.