Better ways to check and use medical-record data for people with HIV
Statistical methods and designs for correlated outcome and covariate errors in studies of HIV/AIDS
This project creates methods to combine routine medical records with carefully checked samples so HIV research gives more accurate answers for people living with HIV.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11469941 on NIH RePORTER |
What this research studies
Researchers will build statistical methods and software that combine routine electronic health record (EHR) data with smaller sets of records that are validated by experts. They will design efficient, multi-wave strategies to choose which patient records to re-check in order to correct errors that affect several measurements at once. The methods aim to remove bias and tighten estimates so study results are more trustworthy. These approaches will be tested using existing HIV datasets such as the International epidemiology Databases to Evaluate AIDS (IeDEA).
Who could benefit from this research
Good fit: Ideal candidates are people living with HIV whose medical records are held at participating clinics or databases and who could have a subset of their records validated.
Not a fit: People without EHRs at participating sites or whose records are not selected for validation are unlikely to be directly involved or to see immediate benefits.
Why it matters
Potential benefit: If successful, this work could make HIV research based on medical records more reliable, leading to better-informed clinical guidelines and care for people with HIV.
How similar studies have performed: Related methods have been developed and applied to HIV datasets (including IeDEA) before, and this project extends those approaches to handle correlated errors and optimal validation designs.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Shepherd, Bryan Earl — Vanderbilt University Medical Center
- Study coordinator: Shepherd, Bryan Earl
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.