Better tools to map the cell's protein-cleanup system (ubiquitin-proteasome)
Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome System
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11174356
This project builds improved protein-mapping methods to show how the ubiquitin-proteasome system works in cancer cells.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11174356 on ClinicalTrials.gov |
What this research studies
Researchers are developing advanced mass‑spectrometry and cross‑linking techniques that 'freeze' and map how proteins interact inside cells. They will apply these tools to chart the dynamic machines that tag and break down proteins (the ubiquitin‑proteasome system), especially as they change in cancer. The work is largely done in the lab using cells and biological samples to create detailed maps of protein complexes and their structural features. Over time these maps could point to new drug targets or biomarkers for cancer treatment.
Who could benefit from this research
Good fit: People with cancer who can donate tumor tissue or other clinical samples for proteomics research would be the most directly relevant contributors.
Not a fit: Individuals without cancer or whose condition is unrelated to ubiquitin‑proteasome dysfunction are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this could uncover new targets and biomarkers by revealing how protein degradation goes wrong in cancer.
How similar studies have performed: Related cross‑linking mass spectrometry approaches have successfully mapped many protein complexes, but applying them broadly to whole ubiquitin‑proteasome networks in cancer is a newer and technically challenging aim.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, LAN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: HUANG, LAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers