Better tests to find aggressive prostate cancer earlier
Administrative Core
New urine and tissue tests to find aggressive prostate cancer earlier in men with elevated PSA.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11163350 on NIH RePORTER |
What this research studies
This project brings together University of Michigan, Vanderbilt, and industry partners to create and scale lab-grade tests that detect aggressive prostate cancer. The team will measure cancer-specific gene fusions and RNA biomarkers in urine and tissue samples, building on the existing MyProstateScore test. Assays will be optimized in a CLIA laboratory and validated using clinical samples to ensure they reliably pick out cancers that need treatment. The goal is to give men clearer information when deciding whether to have a prostate biopsy.
Who could benefit from this research
Good fit: Men with elevated PSA, abnormal prostate exams, or who are considering a prostate biopsy would be the ideal candidates.
Not a fit: Men without prostate cancer risk factors, those already diagnosed and under treatment, or people outside participating centers may not directly benefit.
Why it matters
Potential benefit: Could help men avoid unnecessary biopsies and catch dangerous prostate cancers earlier when curative treatment is more likely.
How similar studies have performed: Related tests like MyProstateScore have already been used clinically and this project builds on that prior success.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Chinnaiyan, Arul M — University of Michigan at Ann Arbor
- Study coordinator: Chinnaiyan, Arul M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.