Better statistical tools for Long COVID and COVID-19
Statistical Methods in COVID-19/PASC Clinical Research
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11286619
This project builds new statistical methods to help doctors and scientists understand how COVID-19 leads to long-term symptoms (Long COVID/PASC) in patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11286619 on ClinicalTrials.gov |
What this research studies
From a patient viewpoint, researchers at Massachusetts General Hospital are creating new statistical methods to link clinical records, lab markers, and social factors to Long COVID outcomes. They will adapt causal mediation approaches and other advanced techniques to trace pathways from SARS-CoV-2 infection to persistent symptoms or recovery. The team will test these tools using existing COVID-19 datasets and biological samples and will share the methods so other teams can run better studies. This work focuses on improving how research is done and does not provide direct treatments to participants.
Who could benefit from this research
Good fit: People who had COVID-19, especially those with ongoing symptoms after infection (Long COVID/PASC), are most relevant to this work.
Not a fit: If you never had COVID-19, do not have ongoing post-infection symptoms, or are seeking immediate treatment, this project is unlikely to offer direct personal benefits.
Why it matters
Potential benefit: If successful, these tools could clarify causes and subtypes of Long COVID and help design more effective clinical trials and treatments.
How similar studies have performed: Some advanced statistical approaches have helped identify COVID-19 risk factors before, but applying causal mediation and tailored methods specifically to Long COVID is relatively new and still being developed.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOULKES, ANDREA S — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: FOULKES, ANDREA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.