Better Sepsis Care Using Advanced Genetic Information
Improving Sepsis Care with Deep RNA Sequencing Data
This project aims to improve how we diagnose and treat sepsis by looking closely at the genetic material in the blood of patients with this serious condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11124030 on NIH RePORTER |
What this research studies
Sepsis is a life-threatening condition, and this work seeks to find new ways to help patients. We are collecting blood samples from people with sepsis to analyze their RNA, which carries genetic instructions. By examining this RNA, we hope to identify the specific germs causing the infection, predict how a patient might recover, and discover new ways to treat the disease. This approach involves advanced computer analysis to uncover hidden clues in the genetic data that could lead to more effective care.
Who could benefit from this research
Good fit: This research focuses on understanding sepsis in critically ill patients, particularly those experiencing severe infections.
Not a fit: Patients who do not have sepsis or are not critically ill would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to faster and more accurate diagnosis of sepsis, better predictions of patient outcomes, and the discovery of new treatments for this critical illness.
How similar studies have performed: While RNA sequencing is a known technique, applying deep RNA sequencing and novel computational methods to identify pathogens and host responses in sepsis in this comprehensive way is a cutting-edge approach.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Monaghan, Sean Farrell — Rhode Island Hospital
- Study coordinator: Monaghan, Sean Farrell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.