Better laboratory models for lung adenocarcinoma
Full Project 4 - Lung
This project is building lab-grown lung cancer models that match the genetic changes seen in high-risk patients so researchers can test targeted drugs more accurately.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11180974 on NIH RePORTER |
What this research studies
From the patient's view, scientists will first map the key driver gene changes in lung adenocarcinoma tumors. They will create new cell lines and grow 2D and 3D lab models from alveolar epithelial cells that reflect those patient-specific mutations. These models will be used to test how different targeted therapies work on tumors with different genetic profiles. The work brings together chemistry, engineering, and genetics teams to fill gaps in models for patient groups who currently lack good lab systems.
Who could benefit from this research
Good fit: People with lung adenocarcinoma—especially those with specific driver mutations or from patient groups currently underrepresented in research—would be most relevant to the results of this work.
Not a fit: People without lung cancer or those with other lung cancer types (for example, small cell lung cancer) are unlikely to benefit directly from this project's outcomes.
Why it matters
Potential benefit: If successful, this work could speed up discovery of targeted treatments that work for patients whose tumors are underrepresented in current lab models.
How similar studies have performed: Targeted drugs have helped patients with some LUAD mutations, but creating lab models that reflect high-risk or underrepresented patient groups is relatively novel and less established.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Huang, Yong — University of Florida
- Study coordinator: Huang, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.