Better lab models and genetics for lung adenocarcinoma
Full Project 4 - Lung
Building lab-grown lung cancer models that match patients' genetic changes so treatments can be more precisely matched to people with lung adenocarcinoma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11187178 on NIH RePORTER |
What this research studies
This project aims to make new lung adenocarcinoma cell models that reflect the genetic changes seen in patients, especially from groups that have been under-studied. Researchers will create cells from alveolar epithelial origins and grow them in more realistic 3-D systems in the lab. They will test how different targeted drugs work on these models and compare responses across genetic subtypes. These steps are meant to help link specific gene changes to likely treatment responses.
Who could benefit from this research
Good fit: People with lung adenocarcinoma—especially those whose tumors have specific driver gene mutations or who belong to demographic groups that have been underrepresented in past research—are the ideal focus of this work.
Not a fit: Patients with other types of lung cancer (for example, small cell lung cancer) or those needing immediate standard treatment rather than research participation are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could speed up development of targeted therapies and help doctors choose treatments that better match a patient's tumor genetics.
How similar studies have performed: Some targeted therapies (like those for EGFR or ALK mutations) have helped certain LUAD patients, but developing patient-matched lab models for under-studied groups is a newer and less-tested approach.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Offringa, Ite a — University of Southern California
- Study coordinator: Offringa, Ite a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.