Better immune testing to improve cancer immunotherapy
High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy Trials
This project uses detailed immune and microbiome tests to help doctors understand why some people with cancer respond to immunotherapy and others do not.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11129789 on NIH RePORTER |
What this research studies
Researchers collect tumor tissue, blood, and gut microbiome samples from people taking part in cancer immunotherapy trials and run advanced lab tests to profile immune cells, proteins, and microbes. Four major cancer centers coordinate standardized sample processing and share data so results from many trials can be combined. Computational teams analyze the large, high-dimensional datasets to find patterns linked to treatment response, resistance, or side effects. The effort aims to produce reliable biomarkers that could guide future treatment choices and trial designs.
Who could benefit from this research
Good fit: Ideal candidates are people with cancer who are enrolled in or eligible for immunotherapy clinical trials at participating centers.
Not a fit: People not receiving immunotherapy or not enrolled in related clinical trials are unlikely to directly benefit from participating in this project.
Why it matters
Potential benefit: If successful, this work could help doctors predict who will benefit from immunotherapy and reduce harmful side effects by guiding treatment decisions.
How similar studies have performed: Smaller studies have identified promising biomarkers like PD-L1, tumor mutation burden, and immune cell signatures, but this coordinated, high-dimensional network is broader and relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Gnjatic, Sacha — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gnjatic, Sacha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.