Better HIV and Malaria Treatment for Children in Africa
Optimizing HIV-malaria treatment in a shifting treatment and resistance landscape in Africa
This research aims to understand how new HIV medicines interact with malaria treatments in children living in Africa, to make sure they get the safest and most effective care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11144251 on NIH RePORTER |
What this research studies
Many children in sub-Saharan Africa face the challenge of having both HIV and malaria at the same time. New HIV medications, like dolutegravir (DTG), are now widely used, but we need to understand how they interact with common malaria treatments. These interactions could affect how well the medicines work or cause unexpected side effects. This project will look closely at how these drugs behave in children's bodies to ensure their treatments are as safe and effective as possible.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be children in sub-Saharan Africa who are living with HIV and also need treatment for malaria.
Not a fit: Patients who are adults or do not have both HIV and malaria may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to clearer guidelines for treating children with both HIV and malaria, improving their health outcomes.
How similar studies have performed: While some drug interactions have been observed with similar medications, the specific interactions between new HIV drugs and malaria treatments in children need urgent and novel assessment.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Parikh, Sunil — Yale University
- Study coordinator: Parikh, Sunil
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.