Better Diagnosis for Children's Brain Tumors Using Optical Genome Mapping
Optical Genome Mapping As a Novel Diagnostic Approach in Pediatric Brain Tumors
This project aims to find faster and more accurate ways to diagnose brain tumors in children by using a new technology called Optical Genome Mapping.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11143011 on NIH RePORTER |
What this research studies
Currently, diagnosing pediatric brain tumors often relies on tests that can miss important genetic changes or take a long time to provide results. This can delay finding the best treatment for children. Our team is exploring a new technology, Optical Genome Mapping (OGM), which can find these hidden genetic changes more quickly and completely. By using OGM alongside existing tests, we hope to give doctors a clearer picture of a child's tumor, leading to more precise and timely treatment plans.
Who could benefit from this research
Good fit: This research is most relevant for children diagnosed with brain tumors, especially those whose tumors have been difficult to fully characterize with standard genetic tests.
Not a fit: Patients who do not have pediatric brain tumors or whose tumors are already well-understood by current diagnostic methods may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate and rapid diagnoses for children with brain tumors, allowing for more effective and personalized treatment strategies.
How similar studies have performed: Preliminary data from this team using Optical Genome Mapping on pediatric brain tumor samples has already shown promise in identifying important genetic changes.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Bornhorst, Miriam a. — Lurie Children's Hospital of Chicago
- Study coordinator: Bornhorst, Miriam a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.