Better CT scans for COPD using virtual imaging
Accuracy and Precision in CT Quantification of COPD Through Virtual Imaging Trials
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11136452
This project uses computer-generated CT images and AI to make CT measurements more reliable for people with COPD.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11136452 on ClinicalTrials.gov |
What this research studies
If you have COPD, this project aims to make CT scan measurements more consistent across different machines so doctors can track lung disease more accurately. Researchers create realistic virtual patients and simulated CT scans to test how scanner differences and settings change lung measurements. They use AI algorithms and comparison with real patient image data to tune and harmonize imaging methods without asking people to get extra scans. The goal is to reduce variability so CT-based biomarkers can be trusted for tracking COPD over time.
Who could benefit from this research
Good fit: People with diagnosed COPD who have had or can provide chest CT images, or who can come to Duke for imaging, would be candidates to contribute data or participate in related imaging visits.
Not a fit: People without COPD or those who cannot undergo CT imaging (for example, due to pregnancy or contraindications) are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could make CT-based measures of COPD more accurate and comparable across hospitals, helping doctors monitor disease and tailor care.
How similar studies have performed: Previous work such as the COPDGene project has shown quantitative CT can help characterize COPD, but using virtual imaging trials to harmonize scanners is a newer approach.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABADI, EHSAN — DUKE UNIVERSITY
- Study coordinator: ABADI, EHSAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Chronic Obstruction Pulmonary Disease