Better correction for head movement during brain MRI scans
Comprehensive prospective correction of head motion in functional MRI
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11370326
This project builds tools to reduce errors from head movement during brain MRI scans so images are clearer for children and others who move.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11370326 on ClinicalTrials.gov |
What this research studies
From a patient's point of view, the team is creating scanner software that measures head motion in real time and adjusts image capture to reduce artifacts. They will also track related effects like magnetic field (B0) and receiver sensitivity (B1) and correct those during scan acquisition, image reconstruction, and later data analysis. The goal is to make these acquisition and analysis tools easy to share so other hospitals and researchers can use them. Better motion correction should produce more stable, higher-quality brain imaging for groups who struggle to stay still, such as young children.
Who could benefit from this research
Good fit: Ideal candidates include young children and other people who have difficulty staying still during MRI who can come to the imaging center for scans.
Not a fit: People whose care does not rely on functional MRI or who are unable or unwilling to travel to the imaging site are unlikely to benefit directly from participating.
Why it matters
Potential benefit: If successful, scans will be more reliable and usable for diagnosing and researching brain function in people who move during MRI, especially children.
How similar studies have performed: Prior motion-correction methods have helped but did not fully remove secondary artifacts, and this project applies a more comprehensive, novel approach building on those partial successes.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FROST, STEPHEN ROBERT — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: FROST, STEPHEN ROBERT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.