Better acoustic microscopes for clearer images of tiny tissue samples
Next Generation Quantitative Acoustic Microscopy for Biomedical Application
This project is creating improved acoustic microscopes that make clearer, faster maps of tissue properties to help researchers studying cancer and eye disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11143942 on NIH RePORTER |
What this research studies
Researchers are building a new generation of quantitative acoustic microscopes that combine coded-excitation and data-science methods to produce higher-quality images and much faster scans of very thin tissue sections. They will test the technology on standard resolution targets, artificial tissue phantoms, guinea-pig eye tissue, and cancerous human lymph node samples. The team aims to make instruments that are lower-cost and simple enough for technicians to use like a conventional microscope. If successful, the tools would be used in research labs and microscopy suites to reveal mechanical and acoustic tissue details not available with other microscopes.
Who could benefit from this research
Good fit: Patients who undergo lymph node removal for cancer could potentially contribute surgical tissue samples to this work.
Not a fit: People looking for a direct clinical treatment or immediate medical benefit should not expect one, since this is a lab instrument development project using tissue samples rather than a therapy trial.
Why it matters
Potential benefit: If successful, this could help researchers better characterize cancerous tissues and eye disease at very fine scale, which may accelerate development of diagnostics or treatments.
How similar studies have performed: Quantitative acoustic microscopy is an established research technique for high-resolution tissue mapping, but applying coded-excitation and modern data-science to make it faster, cheaper, and easier to use is a novel approach.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mamou, Jonathan — Weill Medical Coll of Cornell Univ
- Study coordinator: Mamou, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.