Beta-amyloid build-up in the brain for Parkinson's disease
Official title: Build-up of beta-amyloid in the brain in Parkinson's disease
Funded at Universidad Central Del Caribe · NIH-11128713 · Data updated 2026-11-12
This research explores how a protein called amyloid beta, often linked to Alzheimer's, builds up in the brains of people with Parkinson's disease, especially when dementia develops.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Universidad Central Del Caribe NIH-funded |
| Lab location | 1 site (Bayamon, United States) |
| Project start | July 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $104,756 |
| NIH project number | 5SC3GM143983-04 |
| Project ID | NIH-11128713 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is for patients with Parkinson's disease, especially those who may be experiencing or are at risk for developing dementia.
✕Less likely to help
Patients without Parkinson's disease or those not experiencing cognitive decline related to the condition may not directly benefit from this specific research.
What this research studies
We know that a protein called amyloid beta, or Aβ, is a key feature of Alzheimer's disease, but it also appears in people with Parkinson's disease, particularly as Parkinson's-related dementia progresses. About half of those with advanced Parkinson's dementia show brain changes similar to Alzheimer's, including Aβ plaques and tau tangles. Our team is looking into whether ongoing inflammation in the brain causes blood platelets to become overactive, releasing Aβ that then travels from the blood into brain tissue and causes damage. We are investigating if reducing platelet activity or the amount of Aβ carried in the blood can prevent this build-up.
Why it matters
Potential benefit: Understanding how amyloid beta accumulates could lead to new ways to prevent or slow the progression of dementia in people with Parkinson's disease.
How similar studies have gone: While the link between Aβ and Alzheimer's is well-established, this specific hypothesis about platelet-derived Aβ in Parkinson's disease is a novel approach.
Where this research is happening
-
Universidad Central Del Caribe
Bayamon, United States Active
Researchers
- Principal investigator: Inyushin, Mikhail — Universidad Central Del Caribe
- Study coordinator: Inyushin, Mikhail
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.