Best oxygen targets for newborns with birth-related lung and brain injury
Optimal Oxygenation in Neonatal Lung Injury
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA AT DAVIS · NIH-11319814
This project compares two oxygen level targets during cooling and adds IV sildenafil to see if newborns with lung problems and brain injury recover better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA AT DAVIS (nih funded) |
| Locations | 1 site (DAVIS, UNITED STATES) |
| Trial ID | NIH-11319814 on ClinicalTrials.gov |
What this research studies
If your baby has birth-related brain injury and trouble breathing, doctors will use whole-body cooling and compare two target oxygen ranges for the first 72 hours. They will monitor breathing, blood oxygen, and blood flow to the brain while measuring markers of oxidative stress. The team will also look at how inhaled nitric oxide and IV sildenafil affect the lungs and brain under the different oxygen targets. Drug levels and how cooling changes sildenafil behavior will be measured to guide dosing.
Who could benefit from this research
Good fit: Newborns receiving whole-body hypothermia for moderate to severe hypoxic-ischemic encephalopathy who also have meconium aspiration syndrome or persistent pulmonary hypertension are the ideal candidates.
Not a fit: Babies without HIE or significant neonatal lung disease, older children, and adults would not be eligible and would not benefit from this neonatal-focused work.
Why it matters
Potential benefit: If successful, this approach could reduce brain injury, improve lung blood flow, and lower the need for extracorporeal support in affected newborns.
How similar studies have performed: Therapeutic cooling and inhaled nitric oxide are established treatments and sildenafil is used for neonatal pulmonary hypertension, but combining specific higher oxygen targets with IV sildenafil during cooling is relatively new and not well studied.
Where this research is happening
DAVIS, UNITED STATES
- UNIVERSITY OF CALIFORNIA AT DAVIS — DAVIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAKSHMINRUSIMHA, SATYANARAYANA — UNIVERSITY OF CALIFORNIA AT DAVIS
- Study coordinator: LAKSHMINRUSIMHA, SATYANARAYANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury