Best antibiotic choices for urinary tract infections during pregnancy
Identifying Optimal Antibiotic Regimens to Treat Urinary Tract Infections During Pregnancy
This project compares common antibiotic types and treatment lengths to find safer, more effective options for pregnant people with urinary tract infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11336811 on NIH RePORTER |
What this research studies
We will collect information from pregnant people treated for UTIs and compare different antibiotics and how long they are taken to see which options lead to the fewest complications for mothers and babies. The team will follow people from early pregnancy through delivery and track outcomes such as kidney infections, sepsis, preterm birth, and infant birth weight. Researchers will use medical records and may enroll participants at prenatal clinics to capture treatment details and follow-up data. The goal is to fill gaps in current guidance about which drugs and durations are safest in each trimester.
Who could benefit from this research
Good fit: Pregnant people in the first, second, or third trimester who have a diagnosed urinary tract infection or asymptomatic bacteriuria and receive care at participating clinics.
Not a fit: Non-pregnant people, pregnant people without a UTI, or individuals with severe allergies to the antibiotics being compared would not benefit from participation.
Why it matters
Potential benefit: If successful, this work could give pregnant people and their clinicians clearer guidance on which antibiotics and treatment lengths are safest and most effective, reducing infections and pregnancy complications.
How similar studies have performed: Most prior randomized trials excluded pregnant people and existing evidence is limited, so this project addresses an important evidence gap rather than following an already well-proven path.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Butler, Anne Mobley — Washington University
- Study coordinator: Butler, Anne Mobley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.