Benzene exposure affects inflammation and metabolism
Benzene exposure promotes neuroinflammation and metabolic dysregulation
This study is looking at how low levels of benzene, a common air pollutant, might cause inflammation in the brain and lead to problems like high blood sugar and insulin resistance, using animal models to help us understand the potential risks for people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11019767 on NIH RePORTER |
What this research studies
This research investigates how exposure to low doses of benzene, a common environmental pollutant, may lead to neuroinflammation and metabolic issues such as insulin resistance and high blood sugar levels. The study uses animal models to simulate human exposure and examines the effects on brain cells involved in inflammation. By understanding these mechanisms, the research aims to establish a direct link between benzene exposure and metabolic dysfunction, which could have implications for public health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in urban areas with potential exposure to benzene and related metabolic disorders.
Not a fit: Patients who do not have exposure to benzene or metabolic dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of metabolic disorders linked to environmental pollutants.
How similar studies have performed: Other studies have shown associations between environmental pollutants and metabolic disorders, suggesting that this research builds on existing knowledge rather than being entirely novel.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Sadagurski, Marianna — Wayne State University
- Study coordinator: Sadagurski, Marianna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.