Behavioral safety and fentanyl education for people who use stimulants (BSAFE)
Official title: Behavioral Safety and Fentanyl Education: BSAFE
Funded at Public Health Foundation Enterprises · NIH-11420809 · Data updated 2026-11-12
A patient-facing program adapts an overdose-prevention approach into a personalized plan plus text reminders to help people who use stimulants avoid unintentional fentanyl exposure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Public Health Foundation Enterprises NIH-funded |
| Lab location | 1 site (City of Industry, United States) |
| Project start | September 30, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $622,396 |
| NIH project number | 5R01DA064340-02 |
| Project ID | NIH-11420809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who use stimulants (e.g., cocaine or methamphetamine) and are at risk for unintentional fentanyl use.
✕Less likely to help
People who do not use stimulants or are not at risk for unintentional fentanyl use may not benefit from this intervention.
What this research studies
This project tests a tailored, behavioral intervention called B-SAFE to reduce unintentional fentanyl use among people who use stimulants like cocaine and methamphetamine. Participants receive an individualized prevention plan, weekly text reminders, and connections to stimulant-use treatment options, delivered in a randomized trial against usual care. The study will enroll 160 participants over 16 months, with follow-up every four months to assess safety, feasibility, and impact on overdose risk behaviors. It builds on proven strategies for overdose prevention and aims to make them acceptable and effective for stimulant users who are at high risk. If successful, the program could be implemented in community settings to reduce fentanyl-related harm among this population and connect people to care.
Why it matters
Potential benefit: If successful, patients could experience reduced risk of unintentional fentanyl exposure and improved access to care for stimulant-use treatment.
How similar studies have gone: Some overdose-prevention interventions have shown promise, but adapting them specifically for unintentional fentanyl exposure among stimulant users is relatively novel.
Where this research is happening
-
Public Health Foundation Enterprises
City of Industry, United States Active
Researchers
- Principal investigator: Coffin, Phillip O — Public Health Foundation Enterprises
- Study coordinator: Coffin, Phillip O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.