Bedside blood test to identify types of sepsis
Official title: Clinical Validation of a Point-of-Care Precision Medicine Endotyping Platform
Funded at Prenosis, INC. · NIH-11196745 · Data updated 2026-11-12
A quick blood test that helps identify different immune response types in people with sepsis so doctors can choose more tailored care.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Prenosis, INC. NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $700,000 |
| NIH project number | 5R44GM154602-02 |
| Project ID | NIH-11196745 on NIH RePORTER |
Who could benefit from this research
✓Could help
People hospitalized with suspected or confirmed sepsis or severe infection, especially in emergency departments or intensive care units at participating hospitals, are the intended candidates.
✕Less likely to help
People without acute infection or those not treated at sites using this platform are unlikely to benefit directly from this project.
What this research studies
If you have a severe infection or sepsis, clinicians would take a small plasma sample and measure about 43 protein markers. Those biomarker results are combined with routine medical data using machine learning to classify your immune ‘endotype’—a subgroup that describes how your body is responding. The platform is designed to run at or near the bedside so results can be available in real time to inform treatment decisions. The work builds on a large linked biobank of clinical records and samples from thousands of infected patients to train and validate the tool.
Why it matters
Potential benefit: If successful, this could help doctors pick more appropriate treatments faster and reduce harm from one-size-fits-all approaches.
How similar studies have gone: Related biomarker and endotyping approaches in sepsis and ARDS have shown promise, but delivering real-time, point-of-care classification with AI is relatively new.
Where this research is happening
-
Prenosis, INC.
Champaign, United States Active
Researchers
- Principal investigator: Reddy, Bobby — Prenosis, INC.
- Study coordinator: Reddy, Bobby
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.