Beating platinum-resistant ovarian cancer by finding biomarkers and drug targets
BCCMA: Overcoming chemoresistance in ovarian cancer: Identification and validation of biomarkers and targetable drivers of platinum resistance
Researchers are working to find biological markers and new treatment targets to help people whose ovarian cancer stops responding to platinum chemotherapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Greater Los Angeles Healthcare System NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11109410 on NIH RePORTER |
What this research studies
This collaborative project focuses on high-grade serous ovarian cancer and why tumors become resistant to platinum chemotherapy. Researchers will analyze patient tumor samples and use digital spatial profiling, systems biology, and lab models to map changes in cancer cells and their surrounding tissue. The team aims to pinpoint biomarkers that signal resistance and molecular drivers that could be targeted with new therapies. Findings will be prioritized for follow-up experiments that could lead to tests or treatments for resistant tumors.
Who could benefit from this research
Good fit: People with high-grade serous ovarian carcinoma, especially those whose cancer relapsed or progressed after platinum-based chemotherapy, would be most relevant to this research.
Not a fit: Patients with non-ovarian cancers or early-stage ovarian disease who have not received platinum chemotherapy are unlikely to be helped directly by this project.
Why it matters
Potential benefit: If successful, the work could lead to tests that predict platinum resistance and new therapies for patients with resistant ovarian cancer.
How similar studies have performed: Prior studies have found some markers linked to platinum resistance but durable, widely effective treatments remain limited, so this project builds on existing findings while searching for new, targetable drivers.
Where this research is happening
Los Angeles, United States
- VA Greater Los Angeles Healthcare System — Los Angeles, United States (Active)
Researchers
- Principal investigator: Orsulic, Sandra — VA Greater Los Angeles Healthcare System
- Study coordinator: Orsulic, Sandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.