Baylor diagnostic center for adults with undiagnosed and rare conditions
UDN Diagnostic Center of Excellence at Baylor College of Medicine
Provides adults with unexplained medical problems access to advanced genetic and laboratory testing to help find a diagnosis.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11158816 on NIH RePORTER |
What this research studies
You would work with the Baylor Diagnostic Center to get state-of-the-art testing like genome and exome sequencing plus RNA sequencing on blood and skin cells. The team combines your clinical exam, family history, and laboratory analyses to search for genetic causes of unexplained symptoms. Baylor uses an RNA-sequencing-first approach alongside DNA testing and partners with other NIH programs and community clinics to increase referrals and follow-up. When a cause is found, the team may share potential treatment approaches or next research steps.
Who could benefit from this research
Good fit: Adults (21 years and older) with complex, unexplained medical problems who have not received a diagnosis despite prior testing are the ideal candidates.
Not a fit: People already living with a confirmed diagnosis or children under 21 are unlikely to be eligible or to benefit from this specific program.
Why it matters
Potential benefit: Could provide a diagnosis and point to possible treatment or management options for people with previously unexplained conditions.
How similar studies have performed: Baylor and other Undiagnosed Diseases Network sites have reported meaningful diagnostic success, with Baylor showing about a 38% solve rate and broad adoption of the RNA-first approach.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Brendan — Baylor College of Medicine
- Study coordinator: Lee, Brendan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.