Basonuclin-1 and the progression of inflammatory breast cancer
Official title: The transcription factor basonuclin-1, a new player in the progression of triple-negative inflammatory breast cancer
Funded at University of Puerto Rico Rio Piedras · NIH-11385472 · Data updated 2026-11-12
Researchers are studying how a gene called basonuclin-1 may drive aggressive, hard-to-treat inflammatory breast cancer to help find new ways to stop its spread.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Rio Piedras NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project start | August 6, 2025 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $147,543 |
| NIH project number | 5R16GM159700-02 |
| Project ID | NIH-11385472 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with inflammatory breast cancer, particularly triple-negative cases, or those contributing tumor samples for related studies.
✕Less likely to help
Results may not immediately benefit patients with non-inflammatory or non-triple-negative breast cancer.
What this research studies
This project looks at how the transcription factor BNC-1 might fuel the aggressive behavior and brain metastasis seen in inflammatory breast cancer, especially the triple-negative form. Using 3D cell culture and breast cancer cell lines, the team will explore how BNC-1 affects cell growth, emboli formation, and metastatic traits. The work will analyze RNA sequencing data to pinpoint pathways linked to BNC-1 and test its role in promoting cancerous features in lab models. Outcomes could guide future strategies to target BNC-1 in patients with this deadly cancer.
Why it matters
Potential benefit: If successful, the research could identify new targets to treat or slow the spread of inflammatory breast cancer.
How similar studies have gone: Previous work has linked transcription factors to aggressive breast cancer features, but the specific role of BNC-1 in inflammatory breast cancer is still being explored.
Where this research is happening
-
University of Puerto Rico Rio Piedras
San Juan, United States Active
Researchers
- Principal investigator: Peterson, Esther a — University of Puerto Rico Rio Piedras
- Study coordinator: Peterson, Esther a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.