Bank of bone marrow and blood samples for leukemia and marrow disorders
Sample Processing and Banking
This program collects and preserves bone marrow and blood samples from adults with leukemia and related bone marrow disorders so researchers can use them to develop better treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11196544 on NIH RePORTER |
What this research studies
This program collects bone marrow and blood from adult patients and processes them into cryopreserved samples for long-term research use. Each sample is annotated with pathology, cytogenetics, and flow cytometry data and stored in a secure computerized inventory that protects patient privacy. As of August 2024, the bank contains 16,368 bone marrow samples from 5,130 unique patients, including 2,719 with AML and 1,394 with MDS. Researchers have used the bank to support drug development, study mechanisms of resistance, perform BH3 profiling, and create genomically defined patient-derived xenograft models.
Who could benefit from this research
Good fit: Adults (21+) with AML, MDS, other hematologic malignancies, or healthy adult donors who can provide bone marrow or blood samples and give informed consent under the IRB-approved protocol are appropriate candidates.
Not a fit: Pediatric patients, people without bone marrow disorders, or anyone unable or unwilling to provide bone marrow or blood samples are unlikely to benefit directly from participating, and donors should not expect immediate therapeutic benefit.
Why it matters
Potential benefit: If widely used, the bank could speed development of new therapies, help explain treatment resistance, and support more personalized approaches for patients with leukemia.
How similar studies have performed: Biobanks and annotated tissue banks have a strong track record of enabling discoveries and drug development, and this specific bank has already supported many published studies and PDX resources.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Ritz, Jerome — Dana-Farber Cancer Inst
- Study coordinator: Ritz, Jerome
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.