B cell receptor and antibody analysis hub
Core B: Antigen Receptor Sequencing, Cloning, Expression, and Analysis Core
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11332848
This effort sequences B cell receptors and makes/testing antibodies to track how immune responses to transplants, infections, and self-targets change over time for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11332848 on ClinicalTrials.gov |
What this research studies
From a patient perspective, this program takes blood or tissue samples to read the genetic sequences of B cell receptors, then recreates and tests those antibodies in the lab to see what they bind and how strongly. It follows groups of related B cells over time to watch clonal expansion and the mutations that improve antibody binding. The core provides sequencing, cloning, expression, and binding analysis services to support multiple projects focused on responses to alloantigens, autoantigens, and foreign pathogens. Results help link sequence changes to real changes in antibody behavior rather than relying on sequence data alone.
Who could benefit from this research
Good fit: Ideal participants are people with recent or prior transplants, autoimmune diseases, or active/recent infections who can provide blood or tissue samples for immune profiling.
Not a fit: People without conditions that affect B cells or those unwilling to provide samples are unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could help identify better antibody targets and improve vaccines, transplant monitoring, and treatments for autoimmune or infectious diseases.
How similar studies have performed: B cell receptor sequencing and monoclonal antibody cloning are established techniques with prior successes in vaccine and antibody discovery, though applying them across allo, self, and foreign responses in a coordinated core is a broader effort.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KING, RODNEY GLENN — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: KING, RODNEY GLENN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.