Autism risk in young children with Down syndrome

Autism in Young Children with Down Syndrome

NIH-funded research Colorado State University · NIH-11127701

Researchers will look for early signs and health factors linked to autism in young children with Down syndrome so those most at risk can get support sooner.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionColorado State University NIH-funded
Lab location1 site (Fort Collins, United States)
Project IDNIH-11127701 on NIH RePORTER

What this research studies

If your child joins, researchers will follow a group of 225 young children with Down syndrome at about 18–21 months, 30–33 months, and 42–45 months. At each visit they will measure thinking, communication, motor skills, daily living abilities, and record autism-related behaviors. The team will also gather medical history about factors such as premature birth, low birth weight, infantile spasms, congenital heart defects, sleep problems, and gastrointestinal issues. They will combine the developmental and medical information to find patterns that predict which children show autism signs over time.

Who could benefit from this research

Good fit: Young children with Down syndrome roughly between 18 and 45 months of age whose caregivers can attend three study visits are ideal candidates.

Not a fit: Children without Down syndrome, children older than the study window, or families unable to travel to study visits would not be eligible and would not directly benefit from participation.

Why it matters

Potential benefit: If successful, this work could help identify children with Down syndrome who are at higher risk for autism earlier so they can receive tailored early support.

How similar studies have performed: Standard autism screening tools have worked in general-population toddlers, but applying them specifically to young children with Down syndrome is relatively new and less studied.

Where this research is happening

Fort Collins, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Autistic Disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.