Atlas of advanced colon polyps and nearby primed colon tissue
Comprehensive atlas of advanced adenomas and their surrounding primed colon: A multi-omics evaluation and clinical impact assessment
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-11182670
This project builds a detailed molecular map of advanced colon polyps and the nearby colon tissue to find signs that predict which polyps are likely to turn into cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11182670 on ClinicalTrials.gov |
What this research studies
You would be part of a project that studies tissue removed during colonoscopy from advanced colon polyps and the nearby-looking normal colon. Researchers will run multiple molecular tests (DNA, DNA methylation, RNA, proteins) and examine tissue architecture to compare polyps that later progressed with those that stayed indolent. Samples come from a unique collection of adenomas followed over time, and the team will combine these data into an atlas of features of 'aggressive' versus 'indolent' polyps and of 'primed' surrounding colon. The aim is to pinpoint biomarkers in polyps or nearby tissue that could help doctors decide who needs closer follow-up or preventive care.
Who could benefit from this research
Good fit: Ideal candidates are people who have had advanced adenomas removed during colonoscopy and can provide tissue samples, medical records, and follow-up information.
Not a fit: People without adenomatous colon polyps, with non-adenomatous polyps, or with advanced metastatic colorectal cancer are unlikely to gain direct benefit from this early-lesion focused project.
Why it matters
Potential benefit: If successful, this work could enable tests that identify which colon polyps are likely to become cancer, allowing more personalized surveillance and prevention.
How similar studies have performed: Previous studies have found molecular changes in polyps and nearby tissue but no single reliable predictor exists, so this comprehensive multi-omics atlas is a novel effort building on promising prior findings.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRADY, WILLIAM MALLORY — FRED HUTCHINSON CANCER CENTER
- Study coordinator: GRADY, WILLIAM MALLORY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers